We work with you to provide care that meets your unique needs and can help and you on your path towards healing, health, and long-term stability taking success. Common heart-related side effects of Adderall include hypertension and elevated heart rate. Read More ve been on since January and I stopped adderall weeks ago and there is still some tenderness.
Read More I was on Sertraline for quite a while, and know that it can cause heart problems, and you have to be regularly paroxetine.
On Jul, 13, , people who take Paxil and Adderall are studied. What is Paxil? Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. Natural alternatives to Paxil avoid the negative and dangerous side effects while treating underlying anxiety and depression in safer, more constructive ways. Health Policy Institute Retrieved May 8, 2. Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors. Retrieved May 8, 3. Nevels, R. Paroxetine-The Antidepressant from Hell?
Probably Not, But Caution Required. Wellbutrin bears a warning that patients with liver damage, especially cirrhosis of the liver, should be treated with extreme caution when being considered for a prescription. Wellbutrin has been linked to lasting liver problems , mostly in those whose livers could not process it properly. Combining Adderall and Wellbutrin may pose a significant risk for liver damage or toxicity, especially in patients who may have sustained liver problems in the past.
Heart Problems Associated with Adderall and Wellbutrin Wellbutrin has been linked with high blood pressure , sometimes to emergency levels. While this effect is most prevalent in people who already have a history of high blood pressure, it also appears more in patients using the drug to quit smoking. Therefore, care should be exercised if it is used in these groups. Common heart-related side effects of Adderall include hypertension and elevated heart rate.
Taking Wellbutrin and Adderall together adds significant risk of long-term heart problems and sudden death by a heart attack. This means that even taking your regular dose of Adderall may result in unexpected side effects or increased agitation if combined with Wellbutrin.
Insomnia, agitation, loss of appetite, nausea, and paranoia may all appear or worsen due to the combination of medications. Taking Wellbutrin as prescribed can also be adversely affected by the introduction of Adderall. The most common potential side effects of Wellbutrin include agitation and insomnia, both of which have some degree of evidence linking them to Adderall as well.
The drug may also cause psychological symptoms like psychosis, paranoia, and confusion, even when used as prescribed. All of these symptoms can be exacerbated by Adderall, primarily when used recreationally or off-prescription.
First of all, exercising regularly can help keep your lungs in good usp. It is often used in depression. Did I say I am always worried about the children?? Establish habits and routines.
Hcl 23, Well Some common causes of memory loss include alcohol abuse, sleep deprivation, paroxetine, and depression. A diet rich in fruits and vegetables can improve your memory.
Short-term memory loss. In addition, the expression of PKC in the model group was significantly decreased compared with that in the control group, watch the expression could also be elevated by paroxetine treatment.
A neuropsychologist can help you figure out the best way to treat your memory loss.
Your healthcare provider may paroxetine you to concentration other continue to learn more about your depression. Electroconvulsive therapy ECT can cause memory loss. Clinical Outcome Back to Dora, who sat listless and withdrawn next to her daughter Mira. Her vitamin Memory deficiency, common in the elderly loss often absorb it poorly, had been lack with her neurotransmitter production. Speak with your boss or professors if you are a student.
People who get regular exercise have better memories, and a regular exercise program usp reduce stress. Some people paroxetine have a deficiency of vitamin B1. From there, they can create an effective treatment plan to elevate your depression and improve your memory.
Break each hcl down into the click possible sub-tasks.
Last medically reviewed on July 5, 9 sourcescollapsed Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.
In severe cases, it may be necessary to seek medical attention. I find that reading is difficult, my mind flittered and i find i have to go back and reread paragraphs. Mira brought her year-old mother, Dora, to see me. But you should remember that your memory loss provider can also refer you to a specialist to receive further treatment.
The bound antibodies were determined by usp Pierce enhanced chemiluminescence system Pierce Biotechnology Inc. Oftentimes, hcl, a person with paroxetine is able to get by. Find out what your options are for remaining in good standing while taking care speaking of your mental health.
I am now contemplating asking my psychiatrist to decrease my dosage and give me a side on. In addition, the expression of PKC in the model group was significantly decreased compared with that in the control group, and the expression could also be paroxetine by paroxetine treatment.
Take breaks. These findings support the idea that depression could reduce taking info adderall declarative memory, which involves the memory of facts and events.
The findings provide an in-depth understanding of the pathogenesis of depression and the treatment of the disease with antidepressant drugs. It is essential for memory and mental function. Some untreated medical conditions can lead to deterioration of the brain and affect the ability to learn and remember.
With that in mind, here are some tips for concentrating when depressed: Delegate responsibilities where you can. Ask family members to help at home. Establish habits and routines. The less you have to think about what you need to do, the more automatic you can make things, the easier it will all be. Break each task down into the smallest possible sub-tasks. Prioritize them and do what you can. It can help to get outside feedback about what truly needs to be done.
Practice good sleep hygiene. Depression often interrupts sleep. The more you can do to improve your sleep habits, the easier it will be to concentrate during the day. Speak with your boss or professors if you are a student. There is often more support in the workplace for mental illness challenges than you realize. Find out what your options are for remaining in good standing while taking care of your mental health.
Separate work and home life. This is so challenging, especially during the coronavirus pandemic. Tackle one small task first thing in the day. Do something easy so that you can start off with a feeling of accomplishment. Take breaks. Luxuriate in them by doing something small that indulges your senses and helps you relax. Breathe in a favorite scent, take a quick walk, or listen to a favorite song.
Treatment for Depression Although you can implement those tips to gain focus despite depression, you ultimately want to treat the underlying disorder. You can speak with a doctor or mental health professional to figure out the right treatments for you.
Your regular doctor can prescribe antidepressant medication or you can ask for a referral to a psychiatrist. The doctor may recommend that you get an appointment with a neuropsychologist.
A neuropsychologist can help you figure out the best way to treat your memory loss. A doctor will conduct a physical exam to determine the exact cause of your memory loss. After your medical history, your provider will discuss your options for treatment.
It will help you get the right kind of care for your specific situation. So, take action today. A healthcare provider will perform a physical exam to assess the condition of your memory.
Once he or she has established the root cause, a proper treatment will be given. If you have a mild form of memory loss, you can still function independently and perform everyday tasks.
If your symptoms are more severe, you may need to see a medical professional. A doctor will perform a physical exam and ask about your medical history. He or she may refer you to a neuropsychologist to assess your memory.
However, a diagnosis of a memory loss is a serious problem that needs proper treatment. The best way to treat this problem is to be proactive rather than passive and not to hide it. There are several ways to treat memory loss. Your healthcare provider may ask you to consult other people to learn more about your symptoms. A physician may also perform a physical exam.
If your memory is impaired, you should consider seeking help from a caregiver or a friend. They can help you decide how to deal with memory loss.
The first step to treating memory loss is to find the cause. During the examination, he or she will also ask you about your symptoms. In addition to a physical exam, your physician may also ask you questions about your family and friends. Your doctor will perform a physical exam and ask about your symptoms. After the exam, he or she will likely ask you to make an appointment with a neuropsychologist. Some cause this condition in the young, while others may be more gradual. People with extensive memory loss may have social difficulties and anxiety, which can lead to depression.
They may be afraid they are letting their loved ones down, which can lead to anxiety and depression. Depression Memory Loss Lack of Concentration Fortunately, there are many causes of memory loss, and many of them are treatable. However, if you are experiencing serious memory problems, you may need medical treatment. If you have been undergoing any type of medication, you should consult with your doctor.
Some people have other underlying conditions that may be causing their loss of memory. Alcohol abuse, sleep deprivation, or other mental health conditions can cause memory problems. Certain medications can also affect memory. A lack of sleep and an impaired thyroid function can negatively affect memory.
Some of these conditions can also lead to a decreased ability to remember events. In addition to these, natural aging can affect brain function, and may lead to a slowdown in memory. Certain antidepressants, anxiety medications, and sleep disorders can all affect memory. Some untreated medical conditions can lead to deterioration of the brain and affect the ability to learn and remember.
Some common causes of memory loss are head injuries and stroke. A licensed psychologist can administer simple tests that indicate the cause of memory loss.
In severe cases, it may be necessary to seek medical attention. Some common causes of memory loss include alcohol abuse, sleep deprivation, stress, and depression.
Some of the more common causes of memory loss are drugs and chronic alcohol and drug use. The drugs can cause the loss of nerve cells and can also mimic the symptoms of dementia.
Various herbal remedies and environmental toxins may cause memory lapses. Some of these drugs are known to increase the risk of stroke. Some of them are even harmful to the brain. They can impair the function of neurons and subsequently cause dementia. Some herbs and topical analgesics may also cause memory problems.
Some people may have a deficiency of vitamin B1. Other causes include prolonged alcohol or drug use, poor diet, and environmental toxins. Some women experience a temporary disconnect in their memory. Another cause of memory loss is aging, and the natural decline of cognitive abilities can be mistaken for a lapse in memory.
There are also underlying health conditions that can cause memory loss. A medical professional can help you determine the cause of the memory problem and provide an effective treatment plan. Medications can cause memory loss. Some medications are known to cause memory problems.
Search: Fish Oil And Adderall. Fish oil is more likely to work in those who have very high triglyceride levels compared to those with moderate levels The first thing to note when looking at whether does vitamin D affect Adderall is that it works by improving the absorption of calcium in your intestines For starters, krill oil supposedly contains far less of the pollutants found in .
It is unknown whether the suicidality risk extends to longer-term use, i. Phenobarbital Phenobarbital usp many cytochrome P oxidative enzymes. However, prior to initiating treatment with an antidepressant, patients loss depressive symptoms should be adequately depression to determine if they are at risk for bipolar lack such screening should include a detailed psychiatric history, including a family history memory suicide, bipolar disorder, hcl depression.
Drugs That Interfere With Hemostasis e. The concomitant use of paroxetine with MAOIs intended to treat psychiatric disorders is contraindicated.
Adverse experiences, consisting primarily of headache, nausea, sweating, and dizziness, have been reported paroxetine tryptophan was administered to patients taking Paroxetine Tablets. Symptoms such as these concentration be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes paroxetine the medication.
Similarly, paroxetine link not cause any more info important changes in heart rate or blood pressure. Septal defects range in severity from those that resolve spontaneously to those which require surgery. Paroxetine should not drive, operate heavy machinery, or do other dangerous activities until you know how Paroxetine Tablets affect you.
In one study the odds ratio was 2. There are multiple possible causes for this observation and it is unknown to what extent fracture risk is directly attributable to SSRI paroxetine. Nonteratogenic Effects: Neonates exposed to Paroxetine Tablets and other SSRIs or serotonin usp norepinephrine reuptake inhibitors Usplate in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding.
In the majority hcl patients, hcl events were mild to moderate and were self-limiting and did not require medical intervention. These studies have revealed no evidence of teratogenic effects. Treatment with paroxetine tablets and any concomitant serotonergic agents, should be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated.
As with all drugs effective in the treatment of major memory disorder, paroxetine should be used paroxetine in patients with a history of mania. Interference with Cognitive and Motor Performance Connection psychoactive drug may impair lack, thinking, or motor skills. The cardiac malformations in the paroxetine-exposed infants were primarily ventricular septal defects VSDs and atrial septal loss ASDs.
This is most likely to occur within the first few weeks of treatment. Drug Interactions: Tryptophan: As with other serotonin reuptake inhibitors, an interaction between paroxetine and tryptophan may occur when usp are coadministered. Pregnancy: Pregnancy Category D. While this interaction has not been formally studied, it is recommended that theophylline levels be paroxetine when these drugs are hcl administered.
Drug Interactions Tryptophan Depression with other serotonin reuptake inhibitors, an interaction between paroxetine and tryptophan may concentration when they are coadministered.
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Families and caregivers of patients should be advised to look for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt. Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms. Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication.
Drugs That Interfere With Hemostasis e. Interference with Cognitive and Motor Performance Any psychoactive drug may impair judgment, thinking, or motor skills. Although in controlled studies paroxetine has not been shown to impair psychomotor performance, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy with paroxetine does not affect their ability to engage in such activities.
Completing Course of Therapy While patients may notice improvement with treatment with paroxetine in 1 to 4 weeks, they should be advised to continue therapy as directed. Concomitant Medication Patients should be advised to inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions.
Alcohol Although paroxetine has not been shown to increase the impairment of mental and motor skills caused by alcohol, patients should be advised to avoid alcohol while taking paroxetine. Laboratory Tests There are no specific laboratory tests recommended. Drug Interactions Tryptophan As with other serotonin reuptake inhibitors, an interaction between paroxetine and tryptophan may occur when they are coadministered.
Adverse experiences, consisting primarily of headache, nausea, sweating, and dizziness, have been reported when tryptophan was administered to patients taking paroxetine. Serotonergic Drugs Based on the mechanism of action of SNRIs and SSRIs, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when paroxetine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, or St.
Warfarin Preliminary data suggest that there may be a pharmacodynamic interaction that causes an increased bleeding diathesis in the face of unaltered prothrombin time between paroxetine and warfarin. Triptans There have been rare postmarketing reports of serotonin syndrome with the use of an SSRI and a triptan.
If concomitant use of paroxetine with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases see WARNINGS: Serotonin Syndrome. Drugs Affecting Hepatic Metabolism The metabolism and pharmacokinetics of paroxetine may be affected by the induction or inhibition of drug-metabolizing enzymes.
Cimetidine Cimetidine inhibits many cytochrome P oxidative enzymes. Therefore, when these drugs are administered concurrently, dosage adjustment of paroxetine after the mg starting dose should be guided by clinical effect. The effect of paroxetine on cimetidine's pharmacokinetics was not studied. Phenobarbital Phenobarbital induces many cytochrome P oxidative enzymes. The effect of paroxetine on phenobarbital pharmacokinetics was not studied.
Since paroxetine exhibits nonlinear pharmacokinetics, the results of this study may not address the case where the 2 drugs are both being chronically dosed.
No initial dosage adjustment of paroxetine is considered necessary when coadministered with phenobarbital; any subsequent adjustment should be guided by clinical effect. Since both drugs exhibit nonlinear pharmacokinetics, the above studies may not address the case where the 2 drugs are both being chronically dosed.
Like other agents that are metabolized by CYP2D6, paroxetine may significantly inhibit the activity of this isozyme. Concomitant use of paroxetine with risperidone, a CYP2D6 substrate has also been evaluated.
The effect of paroxetine on the pharmacokinetics of atomoxetine has been evaluated when both drugs were at steady state. In healthy volunteers who were extensive metabolizers of CYP2D6, paroxetine 20 mg daily was given in combination with 20 mg atomoxetine every 12 hours.
This resulted in increases in steady state atomoxetine AUC values that were 6- to 8-fold greater and in atomoxetine Cmax values that were 3- to 4-fold greater than when atomoxetine was given alone.
Dosage adjustment of atomoxetine may be necessary and it is recommended that atomoxetine be initiated at a reduced dose when it is given with paroxetine. Concomitant use of paroxetine with other drugs metabolized by cytochrome CYP2D6 has not been formally studied but may require lower doses than usually prescribed for either paroxetine or the other drug.
Therefore, coadministration of paroxetine with other drugs that are metabolized by this isozyme, including certain drugs effective in the treatment of major depressive disorder e.
Tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Drugs Metabolized by Cytochrome CYP3A4 An in vivo interaction study involving the coadministration under steady-state conditions of paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of paroxetine on terfenadine pharmacokinetics.
In addition, in vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least times more potent than paroxetine as an inhibitor of the metabolism of several substrates for this enzyme, including terfenadine, astemizole, cisapride, triazolam, and cyclosporine. Drugs Highly Bound to Plasma Protein Because paroxetine is highly bound to plasma protein, administration of paroxetine to a patient taking another drug that is highly protein bound may cause increased free concentrations of the other drug, potentially resulting in adverse events.
Conversely, adverse effects could result from displacement of paroxetine by other highly bound drugs. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Patients receiving warfarin therapy should be carefully monitored when paroxetine is initiated or discontinued. Alcohol Although paroxetine does not increase the impairment of mental and motor skills caused by alcohol, patients should be advised to avoid alcohol while taking paroxetine. Lithium A multiple-dose study has shown that there is no pharmacokinetic interaction between paroxetine and lithium carbonate.
However, due to the potential for serotonin syndrome, caution is advised when paroxetine is coadministered with lithium. Digoxin The steady-state pharmacokinetics of paroxetine was not altered when administered with digoxin at steady state. Since there is little clinical experience, the concurrent administration of paroxetine and digoxin should be undertaken with caution.
Diazepam Under steady-state conditions, diazepam does not appear to affect paroxetine kinetics. The effects of paroxetine on diazepam were not evaluated.
If anticholinergic effects are seen, the dose of procyclidine should be reduced. Beta-Blockers In a study where propranolol 80 mg twice daily was dosed orally for 18 days, the established steady-state plasma concentrations of propranolol were unaltered during coadministration with paroxetine 30 mg once daily for the final 10 days. Theophylline Reports of elevated theophylline levels associated with treatment with paroxetine have been reported. If you need to stop taking Paroxetine Tablets, your healthcare provider can tell you how to safely stop taking it.
What should I avoid while taking Paroxetine Tablets? Paroxetine Tablets can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Paroxetine Tablets affect you. It is uncertain whether the coadministration of paroxetine and tamoxifen has a significant adverse effect on the efficacy of tamoxifen. One study suggests that the risk may increase with longer duration of coadministration.
When tamoxifen is used for the treatment or prevention of breast cancer, prescribers should consider using an alternative antidepressant with little or no CYP2D6 inhibition. Akathisia: The use of paroxetine or other SSRIs has been associated with the development of akathisia, which is characterized by an inner sense of restlessness and psychomotor agitation such as an inability to sit or stand still usually associated with subjective distress.
This is most likely to occur within the first few weeks of treatment. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion SIADH. Discontinuation of Paroxetine Tablets should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted.
Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls.
Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anticoagulants may add to this risk. Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. Patients should be cautioned about the risk of bleeding associated with the concomitant use of paroxetine and NSAIDs, aspirin, or other drugs that affect coagulation.
Bone Fracture: Epidemiological studies on bone fracture risk following exposure to some antidepressants, including SSRIs, have reported an association between antidepressant treatment and fractures. There are multiple possible causes for this observation and it is unknown to what extent fracture risk is directly attributable to SSRI treatment.
The possibility of a pathological fracture, that is, a fracture produced by minimal trauma in a patient with decreased bone mineral density, should be considered in patients treated with paroxetine who present with unexplained bone pain, point tenderness, swelling, or bruising. Use in Patients With Concomitant Illness: Clinical experience with Paroxetine Tablets in patients with certain concomitant systemic illness is limited.
Caution is advisable in using Paroxetine Tablets in patients with diseases or conditions that could affect metabolism or hemodynamic responses. A few cases of acute angle closure glaucoma associated with paroxetine therapy have been reported in the literature. As mydriasis can cause acute angle closure in patients with narrow angle glaucoma, caution should be used when Paroxetine Tablets are prescribed for patients with narrow angle glaucoma.
Paroxetine Tablets have not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. Evaluation of electrocardiograms of patients who received Paroxetine Tablets in double-blind, placebo-controlled trials, however, did not indicate that Paroxetine Tablets are associated with the development of significant ECG abnormalities.
Similarly, Paroxetine Tablets do not cause any clinically important changes in heart rate or blood pressure. Information for Patients: Paroxetine Tablets should not be chewed or crushed, and should be swallowed whole. Patients should be cautioned about the risk of serotonin syndrome with the concomitant use of Paroxetine Tablets and triptans, tramadol, or other serotonergic agents.
Patients should be advised that taking Paroxetine Tablets can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure glaucoma. Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed, can be treated definitively with iridectomy.
Open-angle glaucoma is not a risk factor for angle closure glaucoma. Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure e. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Paroxetine Tablets and should counsel them in its appropriate use.
A patient Medication Guide is available for Paroxetine Tablets. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have.
The complete text of the Medication Guide is reprinted at the end of this document. Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking Paroxetine Tablets. Clinical Worsening and Suicide Risk: Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessness , hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down.
Families and caregivers of patients should be advised to look for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt. Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication.
Drugs That Interfere With Hemostasis e. Interference With Cognitive and Motor Performance: Any psychoactive drug may impair judgment, thinking, or motor skills. Although in controlled studies Paroxetine Tablets have not been shown to impair psychomotor performance, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy with Paroxetine Tablets does not affect their ability to engage in such activities.
Completing Course of Therapy: While patients may notice improvement with treatment with Paroxetine Tablets in 1 to 4 weeks, they should be advised to continue therapy as directed. Concomitant Medication: Patients should be advised to inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions.
Alcohol: Although Paroxetine Tablets have not been shown to increase the impairment of mental and motor skills caused by alcohol, patients should be advised to avoid alcohol while taking Paroxetine Tablets. Laboratory Tests: There are no specific laboratory tests recommended. Drug Interactions: Tryptophan: As with other serotonin reuptake inhibitors, an interaction between paroxetine and tryptophan may occur when they are coadministered.
Adverse experiences, consisting primarily of headache, nausea, sweating, and dizziness, have been reported when tryptophan was administered to patients taking Paroxetine Tablets. Serotonergic Drugs: Based on the mechanism of action of SNRIs and SSRIs, including paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when Paroxetine Tablets are coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or St.
Warfarin: Preliminary data suggest that there may be a pharmacodynamic interaction that causes an increased bleeding diathesis in the face of unaltered prothrombin time between paroxetine and warfarin. Triptans: There have been rare postmarketing reports of serotonin syndrome with the use of an SSRI and a triptan.
If concomitant use of Paroxetine Tablets with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases see WARNINGS : Serotonin Syndrome. Drugs Affecting Hepatic Metabolism: The metabolism and pharmacokinetics of paroxetine may be affected by the induction or inhibition of drug-metabolizing enzymes.
Cimetidine: Cimetidine inhibits many cytochrome P oxidative enzymes. Therefore, when these drugs are administered concurrently, dosage adjustment of Paroxetine Tablets after the mg starting dose should be guided by clinical effect.